GOP presidential front-runner Donald Trump came out swinging at Jeb Bush during Saturday night’s Republican debate in the crucial state of South Carolina, blaming his brother for the 9/11 attacks and warning that the former Florida governor’s foreign policy would bring more of the same.

“The World Trade Center came down during your brother’s reign,” Trump said in a jab to former President George W. Bush, who will begin stumping for his brother in South Carolina this week. “Remember that.”

After Marco Rubio defended President Bush’s record, Trump said again, “The World Trade Center came down during the reign of George Bush. He kept us safe? That is not safe.

Earlier in the debate, Bush said he was tired of Trump’s attacks on his family.

“Frankly, I could care less about the insults that Donald Trump gives to me. It’s blood sport for him,” Bush said. “But I am sick and tired of him going after my family.

“While Donald Trump was building a reality TV show, my brother was building a security apparatus to keep us safe and I’m glad he did,” Bush said.

Trump also took aim at former President Bush for the War in Iraq.

“Obviously the War in Iraq was a big, fat mistake, all right?” Trump said. “They lied. They said there were weapons of mass destruction; there were none, and they knew there were none.”

Trump also attacked Bush for saying that the first step in restoring stability to the Middle East is to remove Syrian President Bashar al-Assad.

“Jeb is so wrong, Jeb is absolutely so wrong — you’ve got to fight ISIS first,” Trump said, drawing boos from the audience.

“You know who that is? That’s Jeb’s special interest and lobby talking,” Trump said, drawing louder boos.

Trump later traded fire with Texas U.S. Sen Ted. Cruz after days of escalating tensions between the two candidates.

Cruz blasted Trump on Planned Parenthood, which Trump said “does wonderful things having to do with women’s health (but) not as it relates to abortion.”

“He supports federal government funding for Planned Parenthood,” Cruz said. “I disagree with him on that.”

Trump retorted, calling Cruz “the single biggest liar.”

“You are probably worse than Jeb Bush,” Trump said, citing claims that Cruz campaign officials told Iowa caucus-goers that retired neurosurgeon Dr. Ben Carson was dropping out of the race, and charging Cruz with launching anti-Trump robocalls in South Carolina.

Said Trump: “He’s a nasty guy.”

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