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WASHINGTON (AP) -- Secretary of State appointee Hillary Rodham Clinton intervened at least six times in government issues directly affecting companies and others that later contributed to her husband's foundation, an Associated Press review of her official correspondence found.

The overlap of names on former President Bill Clinton's foundation donor list and business interests whose issues she championed raises new questions about potential ethics conflicts between her official actions and her husband's fundraising. The AP obtained three of the senator's government letters under the Freedom of Information Act.

Clinton was to begin her confirmation hearing Tuesday before the Senate Foreign Relations Committee.

Under an agreement with President-elect Barack Obama, Bill Clinton recently released the names of donors to his foundation, a nonprofit that has raised at least $492 million -- including millions from foreign governments -- to fund his library in Little Rock, Ark., and charitable efforts worldwide on such issues as AIDS, poverty and climate change.

The letters and donations involve pharmaceutical companies and telecommunications and energy interests. An aide to the senator said she made no secret of her involvement in many of the issues. Bill Clinton's foundation declined to say when it received the donations or precisely how much was contributed.

"Throughout her tenure, Senator Clinton has proven that she acts solely based on what she believes is best for the state and people she represents, without consideration to any other factor," spokesman Philippe Reines said. "In these instances, she was doing what the people of New York elected her to do: Work hard on the issues of importance to them."

Hillary Rodham Clinton and the Clinton Foundation both declined to answer questions about whether the senator attempted to step away from issues directly affecting donors to her husband's charity, and whether the foundation tried to screen out money from those on whose issues the senator had intervened.

"Generally, through a combination of rigorous adherence to Senate and FEC income and asset disclosure rules, coupled with the voluntary and unprecedented release of the names of every single Foundation supporter since its inception, the Clintons are by far the most financially transparent former first couple in American history," Reines said.

Sen. Clinton wrote to the Federal Communications Commission in February 2004 expressing concern that changes to competitive local exchange carrier access rates could hurt carriers such as New York-based PAETEC Communications. PAETEC's chief executive is Arunas Chesonis, whose family and charity later contributed to the Clinton foundation.

Sarah Wood, executive director of the Chesonis Family Foundation, was invited by a part of the Clinton Foundation, the Clinton Global Initiative, to join the initiative after it was established in 2005, Wood said Monday. The Chesonis family personally paid $15,000 for Wood's membership in CGI in September 2007, and the Chesonis foundation paid $20,000 for it in March 2008, Wood said.

The Chesonis Family Foundation made a $10 million pledge last May to the Massachusetts Institute of Technology for solar energy research, meeting Wood's commitment to the Clinton Global Initiative to act on a project, Wood said.

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